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Scientists in breakthrough in fight against strokes

By Anna Liesowska
02 March 2015

Clinical trials set to start on cheaper, safer and more efficient stent created by experts in Novosibirsk and Tomsk.

'The company Angioline wanted to improve on the existing US-made device with a cheaper, and more effective, Russian equivalent.' Picture: Institute of Strength Physics and Materials Science

Scientists in Siberia have taken a step forward in the fight against strokes by developing a cheaper and more effective device to prevent the condition.

An American-manufactured cardio stent, made of titanium nickelide and fitted in a patient's heart, is currently the existing way those at risk are treated.

But now Novosibirsk company Angioline, in conjunction with the Institute of Strength Physics and Materials Science (ISPM) in Tomsk, have come up with an implant where the potentially-dangerous nickel is replaced with silicon.

'It was found that the modified surface after treatment with silicon didn't have any adverse effects and even stimulated cells proliferation,' said Dr Ludmila Meisner, a senior fellow of the ISPM, based at Tomsk Academic City.

Her colleague Professor Sergey Psakhie, a director of the ISMP, added: 'Traditional alloy contains nickel which is dangerous for the human body. Therefore, its ions from the surface of the upper layers we replaced with the silicon, which is biocompatible with living cells.'

Tomsk cardio stent


Tomsk cardio stent

'We have found that the devices are amazingly good installed. The silicon coating promotes cell overgrowth and accelerate the healing process.' Pictures: RIA Novosti, Institute of Strength Physics and Materials Science

The implants hold any blood clots in the heart and do not allow them to go into the artery. 

According to Andrey Kudryashov, director of Angioline, the company wanted to improve on the existing US-made device with a cheaper, and more effective, Russian equivalent.

The nickel in the upper layer of the stent was replaced by 20-30nanometre-thick silicon, with experts at Tomsk Polytechnic University creating the special implanter of the layer.

Tests have been taking place on pigs at the Tomsk Institute of Cardiology.

'We have found that the devices are amazingly good installed,' said Professor Sergey Popov from the Institute. 'The risk of thrombus formation is absent. The silicon coating promotes epithelialization (cell overgrowth) and accelerate the healing process.'

Cardio stent


Cardio stent


Cardio stent

'The nickel in the upper layer of the stent was replaced by 20-30nanometre-thick silicon, with experts at Tomsk Polytechnic University creating the special implanter of the layer.' Pictures: Vesti.ru

Deputy director of the ISPM, Alexander Lotkov, said the new stent provides 1.5 times higher efficiency while the coating improves the corrosion resistance by several times.

According to preliminary estimates, the new device will cost just 50,000-60,000 Roubles (£520-£620), much cheaper than foreign counterparts that can cost up to 500,000 Roubles (£5,200).

Angioline plans to start clinical trials in the near future, with the hope the stent can be available for use next year.

Comments (2)

Brilliant..I hope they get to market quickly..a friend of mine needs something safer, like this ,implanted. Ive lost 2 other friends to bad stents.
Laurel, Australia
31/03/2015 19:12
0
0
What about perivalvular leak? Is this stent only for open heart placement?
Flynn, USA
03/03/2015 07:52
1
0
1

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